Oxfordshire Clinical Commissioning Group
Formulary
 
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8 Malignant disease and immunosuppression
08-01-01 Alkylating drugs

Bendamustine Levact®
Formulary

Red Traffic Light 

  • For the first-line treatment of chronic lymphocytic leukaemia as per NICE TA216 (APCO May 2011).
  • In combination with obinutuzumab for treating follicular lymphoma refractory to rituximab, as per NICE TA472 (APCO November 2017). Funded by specialised commissioning. 

Black Traffic Light 

  • For the treatment of indolent (low grade) non-Hodgkin's lymphoma that is refractory to rituximab as per NICE TA206 (APCO September 2010).
  • In combination with ibrutinib and rituximab for treating relapsed or refractory chronic lymphocytic leukaemia after systemic therapy (NICE TA437 - terminated appraisal). APCO May 2017.
Link  NICE TA216: Bendamustine for CLL
Link  NICE TA472: Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
Link  NICE TA206: Bendamustine for the treatment of indolent (low grade) non-Hodgkin’s lymphoma that is refractory to rituximab
Link  Letter: Bendamustine (Levact) - Increased mortality observed when used in non-approved combination treatments or outside approved indications
 

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Busulfan
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Carmustine Gliadel®
Formulary

Red Traffic Light  For the treatment of newly diagnosed high-grade glioma as per NICE TA121.

Black Traffic Light  For the treatment of recurrent glioblastoma multiforme as per NICE TA149 (terminated appraisal).

APCO September 2010.

Link  NICE TA121: Glioma (newly diagnosed and high grade) - carmustine implants and temozolomide
 

Cytotoxic Drug  View adult BNF  View SPC online  View childrens BNF
Chlorambucil Leukeran®
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Chlormethine Hydrochloride
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Cyclophosphamide
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Estramustine Phosphate Estracyt®
Formulary

Secondary care use only.

APCO July 2008.


Red View adult BNF  View SPC online  View childrens BNF
Ifosfamide
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Lomustine
Formulary

Secondary care use only. 

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Melphalan
Formulary

Secondary care use only.

APCO July 2008.


Cytotoxic Drug  Red View adult BNF  View SPC online  View childrens BNF
Thiotepa Tepadina®
Formulary

Secondary care use only. 


Red View adult BNF  View SPC online  View childrens BNF
Treosulfan
Formulary

Secondary care use only.

APCO July 2008.


Red View adult BNF  View SPC online  View childrens BNF
Mitobronitol
Formulary

Secondary care use only for the treatment of chronic myeloid leukaemia; it is available on a named-patient basis from specialist importing companies.

APCO July 2008.


Red View adult BNF  View SPC online  View childrens BNF