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 Formulary Chapter 2: Cardiovascular system - Full Chapter
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02.02  Expand sub section  Diuretics
02.02.01  Expand sub section  Thiazides and related diuretics
Indapamide
(Standard release)
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First Choice
Green

First choice thiazide for treatment of hypertension.

 
Indapamide MR
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Formulary
Green
 
   
Bendroflumethiazide
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Formulary
Green
 
   
Chlorothiazide 250mg/5ml liquid
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Formulary
Red

Restricted to neonates and paediatric patients with swallowing difficulties.

Available as an unlicensed product.

 
   
Metolazone
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Formulary
Red

For use in secondary care by Cardiology for diuretic resistance and heart failure only.

 
   
02.02.02  Expand sub section  Loop diuretics
Furosemide
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First Choice
Green

First choice diuretic for the management of heart failure. See The Management of Heart Failure in Primary Care. 

 
Bumetanide
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Formulary
Green

May be more effective in patients with heart failure who are severely oedematous. See The Management of Heart Failure in Primary Care. 

 
   
02.02.03  Expand sub section  Potassium-sparing diuretics and aldosterone antagonists
Amiloride Hydrochloride
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Formulary
Green
 
   
02.02.03  Expand sub section  Aldosterone antagonists to top
Spironolactone
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First Choice
Green

Prescribe generically.

If using for heart failure, see The Management of Heart Failure in Primary Care. 

 
Eplerenone
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Formulary
Amber Continuation
  • Second line for patients that cannot tolerate spironolactone (APCO November 2013).
  • First line mineralocorticoid receptor antagonist for young (<65) male patients, to reduce the risk of cardiovascular mortality and morbidity in stable patients with left ventricular dysfunction and clinical evidence of heart failure after recent MI (APCO November 2017). 
 
   
02.02.04  Expand sub section  Potassium-sparing diuretics with other diuretics
Co-amilofruse (Furosemide and amiloride)
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Formulary
Green
 
   
02.02.05  Expand sub section  Osmotic diuretics
Mannitol
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Formulary
Red

Secondary care use only. 

 
   
02.02.06  Expand sub section  Mercurial diuretics
02.02.07  Expand sub section  Carbonic anhydrase inhibitors
02.02.08  Expand sub section  Diuretics with potassium to top
 ....
 Non Formulary Items
Burinex K®

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Non Formulary
 
Centyl K®

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Non Formulary
 
Chlortalidone

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Non Formulary
Link  UKMI Q&A: Where can chlortalidone tablets be obtained from?
 
Co-amilozide  (Amiloride and hydrochlorothiazide)

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Non Formulary
 
Co-flumactone  (Hydroflumethiazide and spironolactone )

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Non Formulary
 
Co-triamterzide  (Triamterene and hydrochlorothiazide)

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Non Formulary
 
Cyclopenthiazide  (Navidrex®)

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Non Formulary
 
Diumide-K Continus®

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Non Formulary
 
Lasikal®

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Non Formulary
 
Neo-NaClex-K®

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Non Formulary
 
Spironolactone and furosemide  (Lasilactone®)

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Non Formulary
 
Torasemide

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Non Formulary
 
Triamterene  (Dytac®)

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Non Formulary
 
Triamterene and chlortalidone  (Kalspare®)

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Non Formulary
 
Triamterene and furosemide  (Frusene®)

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Non Formulary
 
Triamterene and hydrochlorothiazide  (Dyazide®)

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Non Formulary
 
Xipamide  (Diurexan®)

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Red: Medicines which should only be prescribed in secondary care by a specialist.  

Amber Continuation

Amber Continuation: Medicines which should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the GP that the prescribing responsibility has been transferred.   

Amber Shared Care Protocol

Amber Shared Care Protocol: Medicines which are appropriate to be initiated and stabilised by a specialist, once stabilised the medicine may be appropriate for responsibility to be transferred from secondary to primary care with the agreement of a GP and a formal ‘shared care’ agreement. The shared care protocol must be approved by the Area Prescribing Committee Oxfordshire (APCO).   

Green

Green: Medicines which are suitable for initiation and ongoing prescribing within primary care.   

Brown

Brown: Medicines which should only be prescribed in restricted circumstances.  

Black

Black: Medicines which are not recommended for use because of lack of evidence of clinical effectiveness, cost effectiveness or safety.  

OCCG Green

not used  

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