netFormulary Oxfordshire Clinical Commissioning Group NHS
Formulary  
 Search
 Formulary Chapter 2: Cardiovascular system - Full Chapter
Chapter Links...
 Details...
02.05.05  Expand sub section  Drugs affecting the renin-angiotensin system
02.05.05.01  Expand sub section  Angiotensin-converting enzyme inhibitors (ACE inhibitors)
Ramipril
View adult BNF View SPC online View childrens BNF
First Choice
Green

First choice ACE inhibitor in management of heart failure. See The Management of Heart Failure in Primary Care.

 
Lisinopril
View adult BNF View SPC online View childrens BNF
Second Choice
Green

For heart failure, see The Management of Heart Failure in Primary Care. 

 
   
Perindopril Erbumine or Tert-butylamine
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Captopril
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Brown

Restricted for paediatric use.

 
   
Enalapril Maleate
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Brown

Restricted to existing patients. Not to be initiated in new patients.

APCO November 2005.

 
   
02.05.05.02  Expand sub section  Angiotensin-II receptor antagonists
Candesartan
View adult BNF View SPC online View childrens BNF
First Choice
Green

Candesartan is the preferred Angiotensin II receptor antagonist for patients intolerant of ACE inhibitors due to cough.

For heart failure, see The Management of Heart Failure in Primary Care.

 
Losartan
View adult BNF View SPC online View childrens BNF
Second Choice
Green

For patients intolerant of ACE inhibitors due to cough.

 
   
Irbesartan
View adult BNF View SPC online View childrens BNF
Formulary
Green

For patients intolerant of ACE inhibitors due to cough.

 
   
Sacubitril valsartan▼ (Entresto®)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Shared Care Protocol

For the treatment of symptomatic chronic heart failure with reduced ejection fraction in line with Shared Care Protocol.

APCO January 2017.

Report ALL suspected adverse reactions for black triangle drugs to Yellow Card Scheme.

 
Link  NICE TA388: Sacubitril valsartan for heart failure
Link  SMC advice (March 2016)
   
02.05.05.03  Expand sub section  Renin inhibitors
 ....
 Non Formulary Items
Aliskiren  (Rasilez®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

Not recommended for use due to lack of comparative clinical and cost effectiveness data and local guidance.

Link  MHRA: Aliskiren (Rasilez▼): risk of cardiovascular and renal adverse reactions—new contraindications and warnings
 
Azilsartan  (Edarbi®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

No evidence to support place in therapy over other cost-effective alternatives.

APCO September 2012.

 
Captopril and Hydrochlorothiazide  (Capozide®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Captopril and Hydrochlorothiazide  (Co-zidocapt®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cilazapril  (Vascace®)

View adult BNF View SPC online View childrens BNF
Non Formulary

Discontinued in 2014.

 
Cozaar- Comp®
(Losartan & hydrochlorothiazide)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Enalapril and Hydrochlorothiazide  (Innozide®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Eprosartan  (Teveten®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Fosinopril Sodium  (Staril®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Imidapril  (Tanatril®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Carace® Plus)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Lisicostad®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lisinopril and Hydrochlorothiazide  (Zestoretic®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Moexipril  (Perdix®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Olmesartan  (Sevikar®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Perindopril Arginine  (Coversyl® Arginine )

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

Use equivalent dose of perindopril erbumine (also known as tert-butylamine).

Where:
5mg perindopril arginine ≡ 4mg perindopril erbumine

Recommendation from NHSE as part of Items which should not routinely be prescribed in primary care: Guidance for CCGs.

APCO January 2018.

 
Perindopril Arginine and Indapamide  (Coversyl® Arginine Plus)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black

Use equivalent dose of perindopril erbumine (also known as tert-butylamine).

Where:
5mg perindopril arginine ≡ 4mg perindopril erbumine

In line with Medicines Management and Therapeutics Committee decision.

APCO July 2009.

 
Quinapril  (Accupro®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Quinapril and Hydrochlorothiazide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ramipril and Felodipine  (Triapin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sevikar HCT®

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Telmisartan

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Trandolapril  (Gopten®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Trandolapril and Verapamil  (Tarka®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Valsartan

View adult BNF View SPC online View childrens BNF
Non Formulary

Several suppliers are experiencing intermittent supply issues with valsartan products.

 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Red: Medicines which should only be prescribed in secondary care by a specialist.  

Amber Continuation

Amber Continuation: Medicines which should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the GP that the prescribing responsibility has been transferred.   

Amber Shared Care Protocol

Amber Shared Care Protocol: Medicines which are appropriate to be initiated and stabilised by a specialist, once stabilised the medicine may be appropriate for responsibility to be transferred from secondary to primary care with the agreement of a GP and a formal ‘shared care’ agreement. The shared care protocol must be approved by the Area Prescribing Committee Oxfordshire (APCO).   

Green

Green: Medicines which are suitable for initiation and ongoing prescribing within primary care.   

Brown

Brown: Medicines which should only be prescribed in restricted circumstances.  

Black

Black: Medicines which are not recommended for use because of lack of evidence of clinical effectiveness, cost effectiveness or safety.  

OCCG Green

not used  

netFormulary