Theophylline has a narrow therapeutic index and troublesome interactions (especially with macrolides & nicotine).
N.B.PRESCRIBE BY BRAND - Be aware that oral modified release brands of theophylline and aminophylline are NOT interchangeable. All patients need to be maintained on the same brand as initally prescribed for them.
Slo-Phyllin 60/125/250mg capsules are now discontinued due to manufacturing issues. Prescribers will need to review and switch all affected patients who still require theophylline, from Slop-hyllin to alternative preparations.
More advice from the specialist teams will be available shortly.
Red: Medicines which should only be prescribed in secondary care by a specialist.
Amber Continuation: Medicines which should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the GP that the prescribing responsibility has been transferred.
Amber Shared Care Protocol: Medicines which are appropriate to be initiated and stabilised by a specialist, once stabilised the medicine may be appropriate for responsibility to be transferred from secondary to primary care with the agreement of a GP and a formal ‘shared care’ agreement. The shared care protocol must be approved by the Area Prescribing Committee Oxfordshire (APCO).
Green: Medicines which are suitable for initiation and ongoing prescribing within primary care.
Brown: Medicines which should only be prescribed in restricted circumstances.
Black: Medicines which are not recommended for use because of lack of evidence of clinical effectiveness, cost effectiveness or safety.