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 Formulary Chapter 3: Respiratory system - Full Chapter
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03.01.03  Expand sub section  Theophylline
 note 

Theophylline has a narrow therapeutic index and troublesome interactions (especially with macrolides & nicotine).


N.B.
PRESCRIBE BY BRAND - Be aware that oral modified release brands of theophylline and aminophylline are NOT interchangeable. All patients need to be maintained on the same brand as initally prescribed for them.

 

Aminophylline (Phyllocontin Continus®)
View adult BNF View SPC online View childrens BNF
First Choice
Green

Prescribe by brand.

See Maintenance Management of Asthma – Inhaled and Oral Therapies (adults).

APCO September 2017.

 
Aminophylline IV
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Secondary care use only. 

 
Link  UKMI Q&A: Conversion of IV aminophylline dose to oral aminophylline or theophylline
   
Theophylline (Nuelin® SA)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Prescribe by brand.

NB: Not included in the Maintenance Management of Asthma – Inhaled and Oral Therapies (adults).

APCO March 2020.

 
   
Theophylline (Uniphyllin® Continus)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Prescribe by brand.

NB: Not included in the Maintenance Management of Asthma – Inhaled and Oral Therapies (adults).

APCO March 2020.

 
   
 ....
 Non Formulary Items
Theophylline  (Slo-Phyllin®)

View adult BNF View SPC online View childrens BNF
Non Formulary

Slo-Phyllin 60/125/250mg capsules are now discontinued due to manufacturing issues. Prescribers will need to review and switch all affected patients who still require theophylline, from Slop-hyllin to alternative preparations. 

More advice from the specialist teams will be available shortly.

Please see the alert here.

 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Red

Red: Medicines which should only be prescribed in secondary care by a specialist.  

Amber Continuation

Amber Continuation: Medicines which should be initiated or recommended by a specialist for continuation in primary care. The specialist must notify the GP that the prescribing responsibility has been transferred.   

Amber Shared Care Protocol

Amber Shared Care Protocol: Medicines which are appropriate to be initiated and stabilised by a specialist, once stabilised the medicine may be appropriate for responsibility to be transferred from secondary to primary care with the agreement of a GP and a formal ‘shared care’ agreement. The shared care protocol must be approved by the Area Prescribing Committee Oxfordshire (APCO).   

Green

Green: Medicines which are suitable for initiation and ongoing prescribing within primary care.   

Brown

Brown: Medicines which should only be prescribed in restricted circumstances.  

Black

Black: Medicines which are not recommended for use because of lack of evidence of clinical effectiveness, cost effectiveness or safety.  

OCCG Green

not used  

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